Northern Elephant Seal Pups |
My dissertation research examined renal
function and hormonal regulation of metabolism in postweaned
northern elephant seal pups. Because elephant seal pups have adapted
to fasting for 2.5 - 3 months postweaning, they provide an
interesting model to address the issues of water and electrolyte
homeostasis and endocrine regulation during a protracted fasting
period. Some data exists on renal function and endocrine changes
during periods of food restriction and fasting in pinnipeds, however
some of these data are not conclusive and the physiological
mechanisms involved are not well defined. Our previous data showed a
decrease in plasma vasopressin (AVP) along with a decrease in urine
output and increased urine osmolality. This apparent paradox in AVP
concentrations and urine output was addressed in
my dissertation research including a more thorough evaluation
of how osmoregulatory hormones contribute to water and electrolyte
balance during exogenous manipulations by volume-, water- and
salt-loading.
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