Our primary interest is immune
tolerance and dysregulation,
both as a basic immunological phenomenon and as a prelude to disease.
The overall objectives of our research are to define the immunological
abnormalities in models of spontaneous autoimmunity, and to identify the
cells, stimuli and targeted antigens required for autoimmune development.
We work to elucidate the immune
abnormalities in inflammation and
autoimmunity, with an emphasis on factors that trigger and maintain
autoimmune disease. By identifying the dysregulated cytokines, expanded
immune populations and relevant targets of autoimmune attack, we can better
understand the mechanisms by which pathogenic lymphocytes cause damage,
and work to develop strategies for treating autoimmunity.