Chapter Fifteen - Simulating Nuclear and Electronic Quantum Effects in Enzymes

Citation:

Wang, L., Isborn, C. M., & Markland, T. E. (2016). Chapter Fifteen - Simulating Nuclear and Electronic Quantum Effects in Enzymes. In G. A. Voth, Computational Approaches for Studying Enzyme Mechanism Part A (Vol. 577, p. 389 - 418). Academic Press.

Abstract:

Abstract An accurate treatment of the structures and dynamics that lead to enhanced chemical reactivity in enzymes requires explicit treatment of both electronic and nuclear quantum effects. The former can be captured in ab initio molecular dynamics (AIMD) simulations, while the latter can be included by performing ab initio path integral molecular dynamics (AI-PIMD) simulations. Both \{AIMD\} and AI-PIMD simulations have traditionally been computationally prohibitive for large enzymatic systems. Recent developments in streaming computer architectures and new algorithms to accelerate path integral simulations now make these simulations practical for biological systems, allowing elucidation of enzymatic reactions in unprecedented detail. In this chapter, we summarize these recent developments and discuss practical considerations for applying \{AIMD\} and AI-PIMD simulations to enzymes.

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