Publications

26) Berry, M. T.; Castrejon, D.; Hein, J. E. “Oxidative Esterification of Aldehydes Using Mesoionic 1,2,3-Triazolyl Carbene Organocatalysts” Org. Lett.2014, Accepted. Link to paper

25) Abel, G. A. Jr; Cao, B. H.; Hein, J. E.; Ye, T. “Covalent, Sequence-Specific Attachment of Long DNA Molecules to a Surface Using DNA-Templated Click Chemistry” Chem. Commun2014, Accepted. Link to paper

24) Otero de la Roza, A.; Cao, B. H.; Price, I. K.; Hein, J. E.; Johnson, E. R. “Predicting the Relative Solubilities of Racemic and Enantiopure Crystals by Density-Functional Theory.” Angew. Chem. Int. Ed., 2014, Accepted. Link to paper

23) Rodarte, A. L.; Nuno, Z. S.; Cao, B. H.; Pandolfi, R. J.; Quint, M. T.; Ghosh, S.; Hein, J. E.; Hirst, L. S. “Tuning Quantum-Dot Organization in Liquid Crystals for Robust Photonic Applications.” Chemphyschem 2014, 15, 7, 1413-1421.  Link to pape

22) Onstott, T. C.; Magnabosco, C.; Aubrey, A. D.; Burton, A. S.; Dworkin, J. P.; Elsila, J. E.; Grundsfeld, S.; Cao, B. H.; Hein, J. E.; Glavin, D. P.; Kieft, T. L.; Silver, B. J.; Phelps, T. J.; Van Heerden, E.; Opperman, D. J.; Bada, J. L. “ Does Aspartic Acid Racemization Constrain the Depth Limir of the Subsurface Biosphere?” Geobiology, 2014, 12, 1-19. Link to paper

21) Yu, D.; Thai, V. T.; Palmer, L. I.; Veits, G. K.; Cook, J. E.; Read de Alaniz; Hein, J. E. “The Importance of Off-Cycle Species in the Acid-Catalyzed Aza-Piancatelli Rearrangement” J. Org. Chem, 2013, 78, 12784-12789. Link to paper

20) Hein, J. E.; Cao, B. H.; van der Meijden, M.; Leeman, M.; Kellogg, R. M. “Resolution of Omeprazole Using Coupled Preferential Crystallization: Efficient Separation of  a Nonracemizable Conglomerate Salt under Near-Equilibrium Conditions” Org. Proc. Res. Dev., 2013, 17, 946-950 . Link to paper

19) Hein, J. E.; Gherase, D.; Blackmond, D. G. “Chemical and Physical Models for the Emergence of Biological Homochirality” Top. Curr. Chem., 2013, 333, 83-108. Link to paper

18) Burton, A. S.; Elsila, J. E.; Hein, J. E.; Galvin, D. P.; Dworkin, J. P. “Extraterrestrial amino acids identified in metal-rich CH and CB Carbonaceous Chondrites from Antarctica ” Meteorit. Planet. Sci., 2013, 48 (3), 390-402. Link to paper

17) Worrell, B. T.; Hein, J. E.; Fokin, V. V. “Halogen Exchange (Halex) Reaction of 5-Iodo-1,2,3-triazoles: Synthesis and Applications of 5-Fluorotriazoles” Angew. Chem. Int. Ed., 2012, 51, 11791-11794. Link to paper

16) Hein, J. E.; Cao, B. H.; Viedma, C.; Kellogg, R. M.; Blackmond, D. G. “Pasteur’s Tweezers Revisited: On the Mechanism of Attrition-Enhanced Deracemization and Resolution of Chiral Conglomerate Solids” J. Am. Chem. Soc., 2012, 134, 12629-12636. Link to paper

15) Hein, J. E.; Blackmond, D. G. “On the Origin of Single Chirality of Amino Acids and Sugars in Biogenesis” Acc. Chem., 2012, 45 (12), 2045-2054. Link to paper

14) Hein, J. E.; Bures, J.; Lam Y-H; Hughes, M.; Houk, K. N.; Armstrong, A.; Blackmond, D. G. “Enamine Carboxylates as Stereodetermining Intermediates in Prolinate Catalysis” Org. Lett., 2011, 13, 5644-5647. Link to paper

13) Millward, S. W.; Henning, R. K.; Kwong, G. A.; Pitram, S.; Agnew, H. D.; Deyle, K. M.; Nag, A.;  Hein, J. E.; Lee, S. S.; Lim, J.; Pfeilsticker, J. A.; Sharpless, K. B.; Heath, J. R. “Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1” J. Am. Chem. Soc., 2011, 133, 18280-18288. Link to paper.

12) Hein, J. E.; Tse, E.; Blackmond, D. G. “A Route to Enantiomerically Pure RNA Precursors from Nearly Racemic Starting Materials” Nat. Chem., 2011, 3, 704-706. Link to paper

11) Hein, J. E.; Armstrong, A.; Blackmond, D. G. “Kinetic Profiling of Prolinate-Catalyzed α-Amination of Aldehydes” Org. Lett., 2011, 13, 4300-4303. Link to paper

10) Hein, J. E.; Krasnova, L. B.; Iwasaki, M.; Fokin, V. V. “Preparation of Tris((1-benzyl-1H-1,2,3-triazolyl)methyl)amine” Org. Synth., 2011, 88, 238-246. Link to paper

9) Krasnova, L. B.; Hein, J. E.; Fokin, V. V. “Synthesis of 7-Aza-5-deazapurine Analogs via Copper (I)-catalyzed Hydroamination of Alkynes and 1-Iodoalkynes” J. Org. Chem., 2010, 75, 8662-8665. Link to paper

8) Hein, J. E.; Fokin, V. V. “Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) and Beyond: New Reactivity or Copper(I) Acetylides” Chem Soc. Rev., 2010, 39, 1302–1315. Link to paper

7) Hein, J. E.; Tripp. J. C.; Krasnova, L. B.; Sharpless, K. B.; Fokin, V. V. “Copper(I)-Catalyzed Cycloaddition of Organic Azides and 1-Iodoalkynes” Angew. Chem. Int. Ed., 2009, 48, 8018–8021. Link to paper

6) Agnew, H. D.; Rohde, R. D.; Millward, S. W.; Nag, A.; Yeo W.-S.; Hein, J. E.; Pitram, S. M.; Tariq, A. A.; Burns; Krom, R. J.; Fokin, V. V.; Sharpless, K. B.; Heath, J. R., “Iterative In Situ Click Chemistry Creates Antibody-like Protein Capture Agents” Angew. Chem. Int. Ed., 2009, 4944–4948. Link to paper

5) Kwok, S. W.; Hein, J. E.; Fokin, V. V.; Sharpless, K. B. “Regioselective Synthesis of Either 1H- or 2H-1,2,3-Triazoles via Michael Addition to α,β-Unsaturated Ketones” Heterocycles, 2008, 1141–1154. Link to paper

4) Hein, J. E.; Geary, L. M.; Jaworski, A. A.; Hultin, P. G. “Practical Synthesis of Fluorous Oxazolidinone Chiral Auxiliaries from α–Amino Acids” J. Org. Chem., 2005, 70, 9940–9946. Link to paper

3) Hein, J. E.; Hultin, P. G. “Recyclable Supports for Stereoselective 1,3-Dipolar Cycloadditions: Application of a Fluorous Oxazolidinone Chiral Auxiliary” Tetrahedron Asymm., 2005, 16, 2341–2347. Link to paper

2) Hein, J. E.; Zimmerman, J.; Sibi, M. P.; Hultin, P. G. “Stereoselective Conjugate Radical Additions: Application of a Fluorous Oxazolidinone Chiral Auxiliary for Efficient Tin Removal” Org. Lett., 2005, 7, 2755–2758. Link to paper

1) Hein, J. E.; Hultin, P. G. “Asymmetric Aldol Reactions Using a Fluorous Oxazolidinone Chiral Auxiliary” Synlett, 2003, 5, 635–638. Link to paper