|
|
Henry Jay Forman, Ph.D. Professor Associate Editor, Free Radical Biology
& Medicine Co-Director, Atmospheric Aerosols and Health (AAH)
Lead Campus program Education: B.A. Chemistry, Queens College, New York Ph.D. Biochemistry, Columbia University Contact
Information: Phone: 209-228-4370 |
Funding for graduate students is available through the Atmospheric Aerosols and Health (AAH) Lead Campus program (a joint program between UC Merced and UC Davis http://aah.ucdavis.edu or contact me directly.
Representative Publications: (complete bibliography below)
1. Forman, H.J. Use and
abuse of exogenous H2O2 in studies of signal
transduction. Free Radic. Biol. Med. 42: 926–932, 2007.
2. Liu, H., Zhang, H. and Forman, H.J.
Silica induces macrophage cytokines through phosphatidylcholine-specific
phospholipase C with H2O2. Am. J. Respir. Cell Mol. Biol.
doi:10.1165/rcmb.2006-0297OC
3. lles, K.E., Dickinson, D.A.,
Wigley, A,F., Welty, N.E., Blank, V. and Forman, H.J. HNE increases HO-1
through activation of the ERK pathway in pulmonary epithelial cells. Free
Radic. Biol. Med. 39: 355-364, 2005.
4. Forman, H.J., Fukuto, J.M., and Torres, M. Redox
signaling - thiol chemistry defines which reactive oxygen and nitrogen species
can act as second messengers. Am. J. Physiol: Cell Physiol. 287:
C246-C256, 2004.
5. Dickinson, D.A., Iles,
K.E., Zhang, H., Blank, V. and Forman, H.J. Curcumin alters EpRE and AP-1
binding complexes and elevates glutamate-cysteine ligase gene expression. Faseb
J. (January 2, 2003) 10.1096/fj.02-0566fje (Full text - online). Faseb
J. 17: 473-475, 2003 (Print version summary).
Research plan
Our laboratory focuses on the molecular biology
and biochemistry of signal transduction and cellular adaptation to reactive
oxygen species and other electrophiles relevant to the response of the lung to
environmental pollution.
Signal transduction: In response to the types of particles in air pollution, lung
macrophages generates reactive oxygen species (ROS). ROS can cause direct cell
injury. More interestingly, ROS also signal for the activation of transcription
factors, which regulate cytokine production and produce inflammation in lung
diseases. The underlying mechanisms involve hydrogen peroxide acting as a
second messenger in multiple signaling pathways in which activation of protein
kinases, reversible inactivation of protein tyrosine phosphatases, and
transient elevation of intracellular free calcium concentration play key roles.
The mechanisms of activation of these processes and their interactions are
being pursued.
Gene regulation in antioxidant and xenobiotic
defense: In response to toxicants and
oxidative stress, such as in tobacco smoke, cells increase their defenses
through increased synthesis of protective enzymes. These so-called Phase II
enzymes include those responsible for the synthesis of glutathione (GSH), the
major antioxidant in mammalian cells, which also increases. The induction of
Phase II enzymes and GSH allows greater resistance to subsequent challenge by
toxicants. Increased transcription, translation and mRNA stability of Phase II
enzymes have been demonstrated. Our research focuses primarily on the signaling
pathways that regulate transcription of the Phase II genes.
To Forman
@ QSB
Bibliography
of Henry Jay Forman, Ph.D
PEER REVIEWED RESEARCH
1. Forman, H.J. and Feigelson, P.
Kinetic evidence indicating the absence during catalysis of an unbound ferroprotoporphyrin form of tryptophan oxygenase.
Biochemistry 10: 760‑763, 1971.
2. Brady, F.O., Forman, H.J. and Feigelson, P.
The role of superoxide and hydroperoxide in the reductive activation of tryptophan‑2,3‑dioxygenase.
J. Biol. Chem. 246: 7119‑7124, 1971.
3. Forman, H.J. and Feigelson, P.
The effects of allosteric interaction on the kinetics, spectra and tertiary structure of Pseudomonad tryptophan oxygenase.
J. Biol. Chem. 247: 256‑259, 1972.
4. Forman, H.J. and Fridovich, I.
Electrolytic univalent reduction of oxygen in aqueous solution demonstrated with superoxide dismutase.
Science 75: 339, 1972.
5. Brady, F.O., Monaco, M.E., Forman, H.J., Schutz, G. and Feigelson, P.
On the role of copper in activation and catalysis by tryptophan‑2,3‑dioxygenase.
J. Biol. Chem. 247: 7915‑7922, 1972.
6. Forman, H.J., Evans, H.J., Hill, R.L. and Fridovich, I.
Histidine at the active site of superoxide dismutase.
Biochemistry 12: 823‑827, 1973.
7. Forman, H.J. and Fridovich, I.
On the stability of bovine superoxide dismutase: the effects of metals.
J. Biol. Chem. 248: 2645‑2649, 1973.
8. Forman, H.J. and Fridovich, I.
Superoxide dismutase: a comparison of rate constants.
Arch. Biochem. Biophys. 158: 396‑400, 1973.
9. Forman, H.J., Waddell, R., Hamilton, P.B. and Grisolia, S.
Activation of carbamyl phosphate synthase by N‑acetyl‑L‑aspartate.
Biochem J. 143: 63‑66, 1974.
10. Forman, H.J. and Grisolia, S.
The effects of cyanate, carbamyl phosphate and growth on the glutamine dependent carbamyl phosphate synthetase from rat spleen and brain.
Physiol. Chem. & Physics 6: 213‑233, 1974.
11. Forman, H.J. and Kennedy, J.A.
Role of superoxide radical in mitochondrial dehydrogenase reactions.
Biochem. Biophys. Res. Commun. 60: 1044‑1050, 1974.
12. Forman, H.J. and Kennedy, J.
Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid.
J. Biol. Chem. 250: 4322‑4326, 1975.
13. Forman, H.J. and Kennedy, J.
Dihydroorotate dependent superoxide production in rat brain and liver; a function of the primary dehydrogenase.
Arch. Biochem. Biophys. 173: 219‑224, 1976.
14. Forman, H.J. and Kennedy, J.
Effects of chaotropic agents versus detergents on dihydroorotate dehydrogenase.
J. Biol. Chem. 252: 3379‑3387, 1977.
15. Forman, H.J. and Kennedy, J.
Purification and characterization of the superoxide producing primary dihydroorotate dehydrogenase from rat liver mitochondria.
Preparative Biochemistry 7: 345‑355, 1977.
16. Forman, H.J. and Kennedy, J.
Mammalian dihydroorotate dehydrogenase: Physical and catalytic properties of the primary enzyme.
Arch. Biochem. Biophys. 191: 23‑31, 1978.
17. Forman, H.J., York, J.L. and Fisher, A.B.
Mechanism for the potentiation of oxygen toxicity by disulfiram.
J. Pharmacol. Exp. Ther. 212: 452‑455, 1980.
18. Kravetz, G., Fisher, A.B. and Forman, H.J.
The oxygen‑adapted rat model: tolerance to oxygen at 1.5 and 2 ata.
Aviat. Space Environ. Med. 51: 775‑777, 1980.
19. Arad, I.D., Forman, H.J. and Fisher, A.B.
Ascorbate efflux from guinea pig and rat lungs: effect of starvation and O2 exposure.
J. Lab. Clin. Med. 96: 673‑681, 1980.
20. Forman, H.J., Nelson, J. and Fisher, A.B.
Rat alveolar macrophages require NADPH for superoxide production in the respiratory burst.
J. Biol. Chem. 255: 9879‑9883, 1980.
21. Forman, H.J. and Fisher, A.B.
Antioxidant enzymes in rat granular pneumocytes: constitutive levels and effect of hyperoxia.
Lab. Invest. 45: 1‑6, 1981.
22. Jowa, L.B., Fisher, A.B. and Forman, H.J.
Glucose‑dependent chemiluminescence by resting rat alveolar macrophages.
J. Reticuloendothelial Soc. 30: 99‑105, 1981.
23. Forman, H.J., Aldrich, T.K., Posner, M.A. and Fisher, A.B.
Differential paraquat accumulation and redox kinetics in rat lung cells.
J. Pharmacol. Exp. Ther. 221: 428‑433, 1982.
24. Forman, H.J., Williams, J.J., Nelson, J., Daniele, R.P. and Fisher, A.B.
Hyperoxia inhibits stimulated superoxide release by rat alveolar macrophages.
J. Appl. Physiol. 53: 685‑689, 1982.
25. Aldrich, T.K., Fisher, A.B. and Forman, H.J.
Paraquat inhibits mixed‑function oxidation by rat lung.
J. Appl. Physiol. 54: 1089‑1096, 1983.
26. Forman, H.J. and Nelson, J.
Effect of extracellular calcium on superoxide release by rat alveolar macrophages.
J. Appl. Physiol. 54: 1249‑1253, 1983.
To Forman @ QSB
27. Cameron, A.R., Nelson, J.,and Forman, H.J.
Depolarization and increased conductance precede superoxide release by concanavalin A stimulated rat alveolar macrophages.
Proc. Natl. Acad. Sci. USA 80: 3726‑3728, 1983.
28. Forman, H.J., Rotman, E.I. and Fisher, A.B.
The roles of selenium and sulfur‑containing amino acids in protection against oxygen toxicity.
Lab. Invest. 49: 148‑153, 1983.
29. Glass, M., Sutherland, M.W., Forman, H.J. and Fisher, A.B.
Selenium deficiency potentiates paraquat‑induced lipid peroxidation in isolated perfused rat lung.
J. Appl. Physiol. 59: 619‑622, 1985.
30. Sutherland, M.W., Glass, M., Nelson, J., Lyen, Y. and Forman, H.J.
Oxygen toxicity: loss of lung macrophage function without metabolite depletion.
J. Free Radic. Biol. Med. 1: 209‑214, 1985.
31. Sutherland, M.W., Nelson, J., Harrison, G. and Forman, H.J.
The effect of t‑butyl hydroperoxide on NADPH, glutathione and the respiratory burst of rat alveolar macrophages.
Arch. Biochem. Biophys. 243: 325‑331, 1985.
32. Forman, H.J., Nelson, J. and Harrison, G.
Hyperoxia alters the effect of Ca2+ on rat alveolar macrophage superoxide production.
J. Appl. Physiol. 60: 1300‑1305, 1986.
33. Glass, M., Forman, H.J., Rotman, E.I., Clark, J.M., Pietra, G.G. and Fisher, A.B.
Cellular composition of lung lavage in oxygen toxicity.
J. Hyperbaric Med. 1: 107‑121, 1986.
34. Harrison, G. and Forman, H.J.
Progressive loss of the macrophage respiratory burst in oxygen toxicity.
J. Free Radic. Biol. Med. 2: 129‑134, 1986.
35. Dorio, R.J., Nelson, J. and Forman, H.J.
A dual role for calcium in the regulation of superoxide generation by stimulated rat alveolar macrophages.
Biochim. Biophys. Acta 928: 137-143, 1987.
36. Forman, H.J., Dorio, R.J. and Skelton, D.C.
Hydroperoxide induced damage to alveolar macrophage function and membrane integrity: alterations in intracellular free Ca2+ and membrane potential.
Arch. Biochem. Biophys. 259: 457-465, 1987.
37. Dorio, R.J. and Forman, H.J.
Ethanol inhibition of signal transduction in superoxide production by rat alveolar macrophages: A proposed mechanism for ethanol-related pneumonia.
Ann. Clin. Lab. Sci. 18: 190-194, 1988.
38. Dorio, R.J., Hoek, J.B., Rubin, E. and Forman, H.J.
Ethanol modulation of rat alveolar macrophage superoxide production.
Biochem. Pharmacol. 37: 3528-3531, 1988.
39. Robison, T.W., Duncan, D.P. and Forman, H.J.
Kinetics of uptake and distribution of arachidonic acid by rat alveolar macrophages.
Prostaglandins 36: 443-461, 1988.
40. Loeb, G.A., Skelton, D.C., Coates, T.D. and Forman, H.J.
Role of the selenium-dependent glutathione peroxidase in antioxidant defense in rat alveolar macrophages.
Exp. Lung Res. 14: 921-936, 1988.
41. Ryer-Powder, J.E. and Forman, H.J.
Adhering lung macrophages produce superoxide demonstrated with Desferal-Mn(IV).
Free Radic. Biol. Med. 6: 513-518, 1989.
42. Loeb, G.A., Skelton, D.C. and Forman, H.J.
Dependence of mixed disulfide formation in alveolar macrophages upon production of oxidized glutathione: effect of selenium deficiency.
Biochem. Pharmacol. 38: 3119-3122, 1989.
43. Warburton, D., Buckley, S., Cosico, L. and Forman, H.J.
Sublethal oxidant injury inhibits signal transduction in rat type II pneumocytes.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 257: L217-L220, 1989.
44. Forman, H.J. and Kim, E.
Inhibition by linoleic acid hydroperoxide of rat alveolar macrophage superoxide production: effects upon mitochondrial and plasma membrane potentials.
Arch. Biochem. Biophys. 274: 443-452, 1989.
45. Robison, T.W., Duncan, D.P. and Forman, H.J.
Chemoattractant and leukotriene B4 production from rat alveolar macrophages exposed to nitrogen dioxide.
Am. J. Respir. Cell Mol. Biol. 3: 21-26, 1990.
46. Forman, H.J. and Skelton, D.C.
Protection of alveolar macrophages from hyperoxia by gamma‑glutamyl transpeptidase.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 259: L102-L107, 1990.
47. Robison, T.W., Duncan, D.P., Coates, T.D. and Forman, H.J.
Inhibition of production of LTB4 and chemoattractant from rat alveolar macrophages treated with t-butyl hydroperoxide is independent of ATP depletion.
Biochim. Biophys. Acta 1045: 9-16, 1990.
48. Robison, T.W., Sevanian, A. and Forman, H.J.
Inhibition of arachidonic acid release by nordihydroguaiaretic acid and its antioxidant action in rat alveolar macrophages and Chinese hamster lung fibroblasts.
Toxicol. Appl. Pharmacol. 105: 113-122, 1990.
49. Robison, T.W. and Forman, H.J.
t‑Butylhydroperoxide stimulates alveolar macrophage biosynthesis of cyclooxygenase products.
Prostaglandins 40: 13-28, 1990.
50. Walther, F.J., Wade, A.B., Warburton, D. and Forman, H.J.
Ontogeny of antioxidant enzymes in the fetal lamb lung.
Exp. Lung Res. 17: 39-45, 1991.
51. Walther, F.J., Wade, A.B., Warburton, D. and Forman, H.J.
Augmentation of superoxide dismutase activity in alveolar type II cells.
Am. J. Respir. Cell Mol. Biol. 4: 364-368, 1991.
52. Heisterkamp, N., Rajpert-De Meyts, E., Uribe, L., Forman, H.J. and Groffen, J.
Identification of a novel human gamma‑glutamyl cleaving enzyme related to gamma‑glutamyl transpeptidase.
Proc. Natl. Acad. Sci. USA 88: 6303-6307, 1991.
To Forman
@ QSB
53. Chang, M., Shi, M. and Forman, H.J.
Exogenous glutathione protects endothelial cells from menadione toxicity.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 262: L637-643, 1992.
54. Rajpert-De Meyts, E., Shi, M., Chang, M., Robison,T.W., Groffen, J., Heisterkamp, N. and Forman, H.J.
Transfection with gamma‑glutamyl transpeptidase enhances recovery from glutathione depletion using extracellular glutathione.
Toxicol. Appl. Pharmacol. 114: 56-62, 1992.
55. Livingston, F.R., Lui, E., Loeb, G. and Forman, H.J.
Sublethal oxidant stress induces a reversible increase in intracellular calcium dependent on NAD(P)H oxidation in rat alveolar macrophages.
Arch. Biochem. Biophys. 299: 83-91, 1992.
56. Robison, T.W. and Forman, H.J.
Dual effects of nitrogen dioxide upon rat alveolar macrophage arachidonate metabolism.
Exp. Lung Res.19: 21-36, 1993.
57. Robison, T.W., Murphy, J.K., Beyer, L.L., Richters, A. and Forman, H.J.
Depression of stimulated arachidonate metabolism and superoxide production in rat alveolar macrophages following in vivo exposure to 0.5 ppm NO2.
J. Toxicol. Environ. Health 38: 273-292, 1993.
58. Murphy, J.K. and Forman, H.J.
Effects of sodium and pH upon the respiratory burst and pH regulation of rat alveolar macrophages.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 264: L523-532, 1993.
59. Shi, M., Gozal, E., Choy, H.A. and Forman, H.J.
Extracellular glutathione and gamma-glutamyl transpeptidase prevent H2O2-induced injury by 2,3-dimethoxy-1,4-naphthoquinone.
Free Radic. Biol. Med. 15: 57-67, 1993.
60. Murphy, J.K., Livingston, F.R., Gozal, E., Torres, M. and Forman, H.J.
Stimulation of the rat alveolar macrophage respiratory burst by extracellular adenine nucleotides.
Am. J. Respir. Cell Mol. Biol. 9: 505-510, 1993.
61. Shi, M., Iwamoto, T. and Forman, H.J.
gamma‑Glutamylcysteine synthetase and glutathione increase in quinone-induced oxidative stress in bovine pulmonary artery endothelial cells.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 267: L414-L421, 1994.
62. Shi, M.M., Kugelman, A., Iwamoto, T., Tian, L. and Forman, H.J.
Quinone-induced oxidative stress elevates glutathione and induces gamma‑glutamylcysteine synthetase activity in rat lung epithelial L2 cells.
J. Biol. Chem. 269: 26512-26517, 1994.
63. Kugelman, A., Choy, H.A., Liu, R.M., Shi, M., Gozal, E. and Forman, H.J.
gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L-2 epithelial cells.
Am. J. Respir. Cell Mol. Biol. 11: 586-592, 1994.
64. Murphy, J.K., Livingston, F.R., Duncan, D.P., Hoyal, C. and Forman, H.J.
Modulation of the alveolar macrophage respiratory burst by hydroperoxides.
Free Radic. Biol. Med. 18: 37-45, 1995.
65. Thomas, M.J., Robison, T.W., Samuel, M. and Forman, H.J.
Detecting and identifying volatile aldehydes as dinitrophenylhydrazones using gas chromatography mass spectrometry.
Free Radic. Biol. Med. 18: 553-557, 1995.
66. Robison, T.W., Zhou, H. and Forman, H.J.
Modulation of ADP-stimulated inositol phosphate metabolism in rat alveolar macrophages by oxidative stress.
Arch. Biochem. Biophys. 318: 215-220, 1995.
67. Robison, T.W., Samuel, M., Forman, H.J. and Thomas, M.J.
Release of aldehydes from rat alveolar macrophages exposed in vitro to low concentrations of nitrogen dioxide.
Biochim. Biophys. Acta 1256: 334-340, 1995.
68. Liu, R.-M., Hu, H., Robison, T.W. and Forman, H.J.
Differential enhancement of gamma-glutamyl transpeptidase and gamma‑glutamylcysteine synthetase by tert-butylhydroquinone in rat lung epithelial L2 cells.
Am. J. Respir. Cell Mol. Biol. 14: 186-191, 1996.
69. Liu, R.-M., Hu, H., Robison, T.W. and Forman, H.J.
Increased gamma‑glutamylcysteine synthetase and gamma‑glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity.
Am. J. Respir. Cell Mol. Biol. 14: 192-197, 1996.
70. Hoyal, C.R., Gozal, E., Zhou, H., Foldenauer, K. and Forman, H.J.
Modulation of the rat alveolar macrophage respiratory burst by hydroperoxides is calcium dependent.
Arch. Biochem. Biophys. 326: 166-171, 1996.
71. Kaul, N. and Forman, H.J.
Activation of NF- kappa B by the respiratory burst of macrophages.
Free Radic. Biol. Med. 21: 401-405, 1996.
72. Hoyal, C.R., Thomas, A.P. and Forman, H.J.
Hydroperoxide-induced increases in intracellular calcium due to annexin VI translocation and inactivation of plasma membrane Ca2+-ATPase.
J. Biol. Chem. 271: 29205-29210, 1996.
73. Qiu, X., Forman, H.J., Sch_nthal, A.H. and Cadenas, E.
Induction of p21 mediated by reactive oxygen species during the metabolism of aziridinylbenzoquinones by HCT116 cells.
J. Biol. Chem. 271: 31915-31921, 1996.
74. Choi, J., Liu, R.-M. and Forman, H.J.
Adaptation to oxidative stress: Quinone-mediated protection of signaling in rat lung epithelial L2 cells.
Biochem. Pharmacol. 53: 987-993, 1997.
75. Tian, L., Shi, M.M. and Forman, H.J.
Increased transcription of the regulatory subunit of gamma‑glutamylcysteine synthetase in rat lung epithelial L2 cells exposed to oxidative stress or glutathione depletion.
Arch. Biochem. Biophys. 342: 126-133, 1997.
76. Zhou, H., Duncan, R.F., Robison, T.W. and Forman, H.J.
Ca2+-dependent p47phox translocation in hydroperoxide modulation of the alveolar macrophage respiratory burst.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 273: L1042-L1047, 1997.
77. Anderson, C.P., Tsai, J., Park, C.K., Tian, L., Liu, R.M., Forman, H.J. and Reynolds, C.P.
Buthionine sulfoximine alone and in combination with melphalan is highly cytotoxic for human neuroblastoma cells.
Eur. J. Cancer 33: 2016-2019, 1997.
78. Suzuki, Y.J., Forman, H.J. and Sevanian, A.
Oxidants as stimulators of signal transduction.
Free Radic. Biol. Med. 22: 269-285, 1997.
To Forman
@ QSB
79. Kaul, N., Choi, J. and Forman, H.J.
Transmembrane redox signaling activates NF- kappa B in macrophages.
Free Radic. Biol. Med. 24: 202-207, 1998.
80. Kaul, N., Gopalakrishna, R., Gundimeda, U., Choi, J. and Forman, H.J.
Role of protein kinase C in basal and hydrogen peroxide-stimulated NF- kappa B activation in the murine macrophage J774A.1 cell line.
Arch. Biochem. Biophys. 350: 79-86, 1998.
81. Liu, R.-M., Shi, M.M., Giulivi, C. and Forman, H.J.
Quinones increase gamma-glutamyl transpeptidase expression by multiple mechanisms in rat lung epithelial cells.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 274: L330-L336, 1998.
82. Hoyal, C.R., Gir_n-Calle, J. and Forman, H.J.
The alveolar macrophage as a model of calcium signaling in oxidative stress.
J. Toxicol. Environ. Health B Crit Rev. 1: 117-134, 1998.
83. Moellering, D., McAndrew, J., Patel, R.P., Cornwell, T., Lincoln, T., Cao, X., Messina, J.L., Forman, H.J., Jo, H. and Darley-Usmar, V.M.
Nitric oxide dependent induction of glutathione synthesis through increased expression of gamma‑glutamylcysteine synthetase.
Arch. Biochem. Biophys. 358: 74-82, 1998.
84. Forman, H.J., Zhou, H., Gozal, E. and Torres, M.
Modulation of the alveolar macrophage superoxide production by protein phosphorylation.
Environ. Health Perspect. 106 S5:1185-1190, 1998.
85. Liu, R.-M., Gao, L., Choi, J. and Forman, H.J.
gamma‑Glutamylcysteine synthetase: mRNA stabilization and independent subunit transcription by 4-hydroxy-2-nonenal.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 275: L861-L869, 1998.
86. Anderson, C.P., Tsai, J.M., Meek, W.E., Liu, R.-M., Tang, Y., Forman, H.J. and Reynolds, C.P.
Depletion of glutathione by buthionine sulfoximine alone is cytotoxic for human neuroblastoma cell lines via apoptosis.
Exp. Cell Res. 246:183-192, 1999.
87. Moellering, D., Mc Andrew, J., Patel, R.P., Forman, H.J., Mulcahy, R.T., Jo, H. and Darley-Usmar, V.M.
The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for gamma-glutamylcysteine
synthetase and gamma-glutamyl transpeptidase.
FEBS Lett. 448: 292-296, 1999.
88. Gao, L. Kim, K.J., Yankaskas, J.R. and Forman, H.J.
Abnormal glutathione transport in cystic fibrosis airway epithelia.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 277: L113-118, 1999.
89. Torres, M. and Forman, H.J.
Activation of several MAP kinases upon stimulation of rat alveolar macrophages: role of the NADPH oxidase.
Arch. Biochem. Biophys. 366: 231-239, 1999.
90. Choi, J., Liu, R.-M., Kundu, R.K., Sangiorgi, F., Wu, W., Maxson, R. and Forman, H.J.
Molecular mechanism of decreased glutathione content in HIV type 1 Tat-transgenic mice.
J. Biol. Chem. 275: 3693-3698, 2000.
91. Choi, J., Opalenik, S.R., Wu, W., Thompson, J.A. and Forman, H.J.
Modulation of GSH synthetic enzymes by acidic fibroblast growth factor.
Arch. Biochem. Biophys. 375: 201-209, 2000.
92. Lee, Y.J., Galoforo, S.S., Sim, J.E., Ridnour, L.A., Choi, J., Forman, H.J., Corry, P.M. and Spitz, D.R.
Dominant-negative Jun N-terminal protein kinase (JNK-1) inhibits metabolic oxidative stress during glucose deprivation in a human breast carcinoma cell line.
Free Radic. Biol. Med. 28: 575-584, 2000.
93. Jha, N. Jurma, O. Lalli, G. Liu, Y., Pettus, E.H., Greenamyre, J.T., Liu, R.-M., Forman, H.J. and Andersen, J.K.
Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity: implications for ParkinsonŐs disease.
J. Biol. Chem. 275: 26096-26101, 2000.
94. Gir_n-Calle, J. and Forman, H.J.
Phospholipase D and priming of the respiratory burst by H2O2 in NR8383 alveolar macrophages.
Am. J. Respir. Cell Mol. Biol. 23: 748-754, 2000.
95. Liu, R.-M., Borok, Z. and Forman, H.J.
4-Hydroxy-2-nonenal increases gamma-glutamylcysteine synthetase gene expression in alveolar epithelial type II cells.
Am. J. Respir. Cell Mol. Biol. 24: 499-505, 2001.
96. Gao, L., Broughman, J.R., Iwamoto, T. Tomich, J.M., Venglarik, C.J. and Forman, H.J.
Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 281: L24-L30, 2001.
97. Gozal, E., Forman, H.J., and Torres, M.
ADP stimulates the respiratory burst without activation of ERK and AKT.
in rat alveolar macrophages.
Free Radic. Biol. Med. 31: 679-687, 2001.
98. Gao, L., Yankaskas, J.R., Fuller, C.M., Sorscher, E.J., Matalon, S. Forman, H.J. and Venglarik, C.J.
Chlorzoxazone or 1-EBIO increases Na+ absorption across cystic fibrosis airway epithelial cells.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 281: L1123-L1129, 2001.
99. Levonen, A.-L., Dickinson, D.A., Mulcahy, R.T., Forman, H.J., and Darley-Usmar, V.M.
Biphasic effects of 15-deoxy-D12,14 -prostaglandin J2 on glutathione induction and apoptosis in human endothelial cells.
Arterioscler. Thromb. Vasc. Biol. 21: 1846-51, 2001.
100. Gir_n-Calle, J., Srivatsa, K., and Forman, H.J.
Priming
of the alveolar macrophage respiratory burst by H2O2 is
prevented by the phosphatidylcholine-specific phospholipase C
inhibitor, tricyclodecan-9-yl-xanthate (D609).
J. Pharmacol. Exp. Ther. 301: 87-94, 2002.
101.
Moellering, D., Go, Y.-M., Levonen, A.-L., Patel, R.P., Dickinson, D.A.,
Forman, H.J., and Darley-Usmar, V.M.
Induction of glutathione synthesis by oxidized low density lipoprotein: protection from oxidant-mediated cytotoxicity.
Biochem. J. 362: 51-59, 2002.
102. West, J.A.A., Williams, K.J., Toskala E., Nishio, S., Fleschner, C., Forman, H.J., Buckpitt, A.R., and Plopper, C.G.
Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the GSH pool.
Am. J. Pathol. 160: 1115-1127, 2002.
103. Iles, K.E., Dickinson, D.A., Watanabe, N., Iwamoto, T. and Forman, H.J.
AP-1 activation through endogenous H2O2 generation by alveolar macrophages.
Free Radic. Biol. Med. 32: 1304-1313, 2002.
104. Forman, H.J., Torres, M. and Fukuto, J.
Redox signaling.
Mol. Cell. Biochem. 234: 49-62, 2002.
To Forman
@ QSB
105. Dickinson, D.A. and Forman, H.J.
Cellular glutathione and thiols metabolism.
Biochem. Pharmacol. 64: 1021-1028, 2002.
106. Watanabe, N., Dickinson, D.A., Krzywanski, D.M., Iles, K.E., Zhang, H., Venglarik, C.J. and Forman, H.J.
A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 283: L726-736, 2002.
107. Dickinson, D.A., Iles, K.E., Watanabe, N., Iwamoto, T., Zhang, H., Krzywanski, D.M. and Forman, H.J.
4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells.
Free Radic. Biol. Med. 33: 974-987, 2002.
108. Watanabe, N., Iwamoto, T., Dickinson, D.A., Iles, K.E., and Forman, H.J.
Mitochondrial caspase activation in absence of protein synthesis does not require JNK.
Arch. Biochem. Biophys. 405: 231-240, 2002.
109. Iles, K.E. and Forman, H.J.
Macrophage signaling and the respiratory burst.
Immunol. Res. 26: 95-105, 2002.
110. Forman, H.J. and Torres, M.
Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling.
Am. J. Resp. Crit. Care Med. 166: S4-S8, 2002.
111. Dickinson, D.A. and Forman, H.J.
Glutathione in defense and signaling: lessons from a small thiol.
Ann. N.Y. Acad. Sci. 973: 488-504, 2002.
112. Torres, M. and Forman, H.J.
Vanadate inhibition of protein tyrosine phosphatases mimics hydrogen peroxide in the activation of the ERK pathway in alveolar macrophages.
Ann. N.Y. Acad. Sci. 973: 345-348, 2002.
113. Dickinson, D.A., Iles, K.E., Zhang, H., Blank, V. and Forman, H.J.
Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression.
Faseb J. (January 2, 2003) 10.1096/fj.02-0566fje (Full text - online).
Faseb J. 17: 473-475, 2003 (Print version summary).
114. Watanabe, N. and Forman, H.J.
Autooxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells.
Arch. Biochem. Biophys. 411: 145-157, 2003.
115. Watanabe, N., Iwamoto, T., Bowen, K.D., Dickinson, D.A., Torres, M. and Forman, H.J.
Bio-effectiveness of Tat-catalase conjugate: A potential tool for the identification of H2O2-dependent cellular signal transduction pathways.
Biochem. Biophys. Res. Commun. 303: 287-293, 2003.
116. Dickinson, D.A., Moellering, D.R., Iles, K.E., Patel, R.P., Levonen, A.-L. Wigley, A., Darley-Usmar, V.M. and Forman, H.J.
Cytoprotection against oxidative stress and the regulation of glutathione synthesis.
Biol. Chem. 384: 527-537, 2003.
117. West, J.A.A., Van Winkle, L.S., Morin, D., Fleschner, C.A., Forman, H.J., Buckpitt, A.R., and Plopper, C.G.
Repeated inhalation exposures of the bioactivated cytotoxicant naphthalene produce a